Search results for "target [deuteron]"
showing 10 items of 159 documents
Gefitinib in lung cancer therapy. Clinical results, predictive markers of response and future perspectives.
2009
Over the past few years, epidermal growth factor receptor has emerged as one of the most important targets in tumorgenesis and several drugs targeting signal transduction pathways have been developed. The first among these agents to be approved for the treatment of NSCLC was gefitinib, a potent, selective and reversible inhibitor of HER1/EGFR tyrosine kinase activity. The review summarizes its clinical development and the new therapeutic options, with particular focus on predictive markers of susceptibility to this drug.
Peak Power Demand and Energy Consumption Reduction Strategies for Trains under Moving Block Signalling System
2013
Published version of an article in the journal: Mathematical Problems in Engineering. Also available from the publisher at: http://dx.doi.org/10.1155/2013/940936 Open Access In the moving block signalling (MBS) system where the tracking target point of the following train is moving forward with its leading train, overload of the substations occurs when a dense queue of trains starts (or restarts) in very close distance interval. This is the peak power demand problem. Several methods have been attempted in the literature to deal with this problem through changing train's operation strategies. However, most existing approaches reduce the service quality. In this paper, two novel approaches - …
Comparative Analysis of Four New Alternative Types of Roundabouts: “Turbo”, “Flower”, “Target” and “Four-Flyover” Roundabou
2016
Analysis of literature shows that “modern roundabouts” nowadays exist in all European countries, as well as in more than 60 countries elsewhere in the world. Nowadays, a growing number of studies, presented in scientific and professional literature, point out a poor traffic safety characteristics of “standard” two-lane roundabouts and lower capacity then was expected. These problems are resolved in more ways in different countries; however the solution, whereby the number of conflict spots is diminished has proven to be the most successful. Lower number of conflict spots is one of characteristics of the alternative types of roundabouts. The alternative types of roundabouts are usually more …
Development of a Tumor-Derived Extracellular Vesicle Engineering Protocol for Targeted Chemotherapeutic: A Novel Experimental Model using Malignant P…
2023
Alternative Investment Fund Managers Directive and its Impact on Malta’s Financial Service Industry
2016
The introduction of the Directive on Alternative Investment Fund Managers (AIFM Directive 2011/61/EU) in 2013 means a radical transformation of the EU regulatory landscape for the whole alternative investment fund industry. Taking into account the growing meaning of the alternative investment fund industry in Europe, the aim of the paper is to assess the impact the Directive on Alternative Investment Fund Managers (AIFMD) will have on the Alternative Investment Fund Managers (AIFMs) managing Alternative Investment Funds (AIFs) in the EU. The research is based on the case of Malta, which is a quickly growing financial centre. The main findings are based on an analysis of questionnaire respon…
Control of a PTZ camera in a hybrid vision system
2014
In this paper, we propose a new approach to steer a PTZ camera in the direction of a detected object visible from another fixed camera equipped with a fisheye lens. This heterogeneous association of two cameras having different characteristics is called a hybrid stereo-vision system. The presented method employs epipolar geometry in a smart way in order to reduce the range of search of the desired region of interest. Furthermore, we proposed a target recognition method designed to cope with the illumination problems, the distortion of the omnidirectional image and the inherent dissimilarity of resolution and color responses between both cameras. Experimental results with synthetic and real …
Target Therapy in Platinum-Refractory/Resistant Ovarian Cancer: From Preclinical Findings to Current Clinical Practice
2013
Epithelial ovarian cancer (EOC) is the sixth most common malignancy in women. Ovarian tumors consist of several clinical and pathological entities that share an anatomic site. The gold standard treatment, both in front-line and in adjuvant setting, is represented by carboplatin/paclitaxel combination. Conversely, the second-line treatment is not well defined. The response to platinum is the major prognostic factor for survival. In this review we discuss the current views on platinum-refractory/resistant patient treatment only, which includes patients progressing or relapsing within 6 months from the last platinum-based course. Concerning this subgroup, the activity of several conventional d…
Physiological Effects of Thiobencarb Stress in the Eel (<i>Anguilla anguilla</i>)
2002
ヨーロッパウナギ Anguilla anguilla の代謝系へのチオベンカルブの影響と, 中毒からの回復とを評価した. 暴露期間ならびにそれに続く非汚染水中での8日間のウナギの血漿, 筋肉, 肝臓についてグリコーゲン, 脂質およびタンパクを測定した. 暴露により血糖値の上昇が認められたが, 肝臓と筋肉におけるグリコーゲンレベルは著しく低下した. 血中の脂質は増加したが, 肝臓での脂質は顕著に減少した. タンパク質の易動化は, とくに筋肉組織で認められた. ほとんどの代謝障害は, 非汚染水へ移した8日後まで継続した. 以上のチオベンカルブの代謝系への影響はある種のストレス症状であり, 魚類の農薬ストレスを代償しようとする生理的適応の具体例と考えられた.
Sensitivity of the Cherenkov Telescope Array to emission from the gamma-ray counterparts of neutrino events
2021
We investigate the possibility of detection of the VHE gamma-ray counterparts to the neutrino astrophysical sources within the Neutrino Target of Opportunity (NToO) program of CTA using the populations simulated by the FIRESONG software to resemble the diffuse astrophysical neutrino flux measured by IceCube. We derive the detection probability for different zenith angles and geomagnetic field configurations. The difference in detectability of sources between CTA-North and CTA-South for the average geomagnetic field is not substantial. We investigate the effect of a higher night-sky background and the preliminary CTA Alpha layout on the detection probability.
Automatic target recognition using 3D passive sensing and imaging with independent component analysis
2009
We present an overview of a method using Independent Component Analysis (ICA) and 3D Integral Imaging (II) technique to recognize 3D objects at different orientations. This method has been successfully applied to the recognition and classification of 3D scenes.